A new and facile synthesis of N-benzyl-N′-acylureas via reaction of dibenzoylhydrazine carboxamide and benzylamines

Herein, we report a new method of synthesis N-acylureas (E1–5) via reaction dibenzoylhydrazine carboxamide (N,2-bis(4-methoxybenzoyl)hydrazine-1-carboxamide) (C) and various benzylamines. Preparation was performed by the treatment 5,6-diaryl-3-methylthio-1,2,4-triazine (B) with Oxone which leads to oxidation triazine ring cleavage in high yield (82%). Five benzylamine derivatives containing different electron donating withdrawing substituents were used this study. Yields for conversion range 40–55%. The structures intermediates final products characterized confirmed NMR, mass spectrometry single-crystal X-ray crystallography.